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Symbol
Name
ID

Sdhd
succinate dehydrogenase complex, subunit D, integral membrane protein
MGI:1914175

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Carotid paraganglioma

Dysphagia

Adrenal pheochromocytoma

Paraganglioma

Chemodectoma

Paraganglioma of head and neck

Glomus jugular tumor

Glomus tympanicum paraganglioma

Vagal paraganglioma

Extraadrenal pheochromocytoma

Spasticity

Spastic paraparesis

Spastic tetraparesis

Easy fatigability

Frequent falls

Leukoencephalopathy

Progressive leukoencephalopathy

Neuroblastoma

Ataxia

Truncal ataxia

Myoclonus

Vocal cord paralysis

Babinski sign

Cranial nerve paralysis

Expressive language delay

Irritability

Episodic paroxysmal anxiety

Cognitive impairment

Dementia

Motor deterioration

Progressive psychomotor deterioration

Hyperreflexia

Hyperactive deep tendon reflexes

Hyperreflexia in upper limbs

Hyperactive patellar reflex

Dystonia

Loss of ambulation

Recurrent paroxysmal headache

Developmental regression

Global developmental delay

Moderate global developmental delay

Motor delay

Seizure

Focal myoclonic seizure

Generalized myoclonic seizure

Disease(s) Associated with SDHD

Carney-Stratakis syndrome

mitochondrial complex II deficiency

paraganglioma

Mouse Phenotypes		nervous system phenotype	abnormal type I cell of carotid body morphology	abnormal type I cell of carotid body physiology	abnormal adrenal chromaffin cell morphology	abnormal dopaminergic neuron morphology	loss of dopaminergic neurons	decreased neuron number
Availability	Mouse Genotype	nervous system phenotype	abnormal type I cell of carotid body morphology	abnormal type I cell of carotid body physiology	abnormal adrenal chromaffin cell morphology	abnormal dopaminergic neuron morphology	loss of dopaminergic neurons	decreased neuron number
	Sdhd^tm1Jlob/Sdhd⁺
	Sdhd^tm1Jlob/Sdhd^tm2Jlob Tg(CAG-cre/Esr1*)5Amc/0 (conditional)	*
	Sdhd^tm1Jlob/Sdhd^tm2Jlob Th^tm1(cre)Te/Th⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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